Penicillin VK (PenVeeK) and G procaine (WYcillin) currently are recommended as first-line
agents for treating moderately severe skin infections and skin structure. In case of adults,
administering of penicillin G procaine by the deep intramuscular injection onto
outer quadrant of the buttock is preferred. In case of small children and infants, midlateral
aspects of thigh might be a better spot for administration.